BioN was raised by Ghetsis. N specifically does not think that Pokémon should battle and dislikes people that intend on using Pokémon for battling. He has a bad habit of talking too much when he gets worked up. N met Ash and his friends while on-route to Hiun City. He encountered them on the ship and told them that he heard a friend's voice, referring to Pikachu. When he heard the voice of Pikachu heart saying that it loved Ash, N got interested and wanted to meet them. He told them that cases in which humans and Pokémon share such a strong bond are rare. Cilan as a Science Sommelier couldn't readily believe that N could hear the voice of a Pokémon's heart, so he questioned N about it. N didn't answer straight and said he might just be imagining it. He told Cilan that it's not important whether you can hear the voice of a Pokémon's heart or not, but that the hearts of the Trainer and the Pokémon are one. Zekrom and Reshiram interest N quite a bit and when he heard that Ash had encountered Zekrom and was going to try to find Reshiram, he wanted to hear more about his journey. N been looking for answers to his questions: Why are there Pokémon in this world? Why have they been born into this world? Why is the world shaped this way? Are Pokémon really happy now? How do Pokémon become complete entities? N thought that if he met the legendary Pokémon Zekrom and Reshiram, he might understand the world's structure and change the world. He helped rescue Pikachu from Rocket Gang and accused Meowth forgoing Pokémon speak to learn the human language. He was then able to communicate with some nearby Mamanbou who healed Pikachu. He then disembarked in Hiun City, but he said he would definitely see Ash and his friends again someday.
Rescuing BraviaryNero and Bianco are team members that often work together on missions. While transporting a captured Braviary to be used as research material, N managed to break into the truck they were driving at rescue Braviary. The two followed N to a nearby Pokémon Center as they had attached a tracking device to Braviary. They decided to try and reclaim Braviary by breaking into the Pokémon Center. Ash and his friends were there and proved to be a distraction after they realized that Plasma Gang was attacking the Pokémon Center. They followed N who had the tracking device on him now while Ash took Braviary to a save location where it could get away. Realizing that Nero and Bianco had caught up with N, Braviary returned to help N. Realizing that they were now defeated, Nero and Bianco decided to retreat as they were unable to reclaim Braviary. N wished Braviary good luck at it returned to its friends and hoped that he would be able to see it again some day.
Hiroto and the Pokémon Gulf Coast Relief CorpsWhile on a training exercise, Hiroto met Ash and his friends as well as N. N and Hiroto didn't get along too well at first as N didn't like the fact that Hiroto was placing his Pokémon in danger to save humans. Hiroto pointed out to him though that there are times when Pokémon save humans but there are also times when it's the other way around and humans save Pokémon. Hiroto further explained to N that its important to not differentiate whether it's a human or a Pokémon when they are going to a rescue. After spending time with Hiroto's Pokémon, N could tell that they weren't being coerced into helping others and that they genuinely wanted to help others. Realizing that, N seemed to respect Hiroto a bit more.