Dr. Fuji was a scientist with great abilities, especially in the field of cloning Pokémon and even human beings.
After the loss of his daughter, Amber, to a car accident, Dr. Fuji devoted his research into creating a clone of his late daughter using what remained of her conscious energy
The controversial research upset his wife who eventually, could not bear being with Dr. Fuji and divorced him and moved away from him. Dr. Fuji remained convinced he could revive Amber and continued with the research.
His research and his abilities caught the attention of Team Rocket Leader Giovanni who agreed to fund his research further by providing him with a team of scientist and a laboratory on New Island, so long as he would create a superior clone of a Pokémon from a fossil thought to be from an extinct Pokémon called Mew.
His research in creating a clone of Mew was proving to be unsuccessful as none of the clones could survive the cloning process. Just as he thought he created a clone of Mew called Mewtwo successfully he suddenly saw what remained of his late daughter's soul disappear, along with clones of Squirtle, Charmander and Bulbasaur.
However, the Mewtwo clone survived and eventually woke up much to his, and the other scientists delight. Mewtwo was angered at being an experiment and destroyed the laboratory with an explosion which spread across the whole island.
Just before Mewtwo caused the explosion, Dr. Fuji uttered the line ""We dreamed of creating the world's strongest Pokémon... and we succeeded."